Structure and function of the notochord: an essential organ for chordate development

TitleStructure and function of the notochord: an essential organ for chordate development
Publication TypeJournal Article
Year of Publication2005
Refereed DesignationRefereed
AuthorsStemple, D. L.
JournalDevelopment
Volume132
Issue11
Pagination2503 - 2512
Date Published06/2005
ISSN1477-9129
Abstract

The notochord is the defining structure of the chordates, and has essential roles in vertebrate development. It serves as a source of midline signals that pattern surrounding tissues and as a major skeletal element of the developing embryo. Genetic and embryological studies over the past decade have informed us about the development and function of the notochord. In this review, I discuss the embryonic origin, signalling roles and ultimate fate of the notochord, with an emphasis on structural aspects of notochord biology.

DOI10.1242/dev.01812
Short TitleDevelopment