Evolution of DNA Replication Protein Complexes in Eukaryotes and Archaea
|Title||Evolution of DNA Replication Protein Complexes in Eukaryotes and Archaea|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Chia, N., Cann I., & Olsen G. J.|
|Secondary Authors||Ahmed, N.|
Background: The replication of DNA in Archaea and eukaryotes requires several ancillary complexes, including proliferating cell nuclear antigen (PCNA), replication factor C (RFC), and the minichromosome maintenance (MCM) complex. Bacterial DNA replication utilizes comparable proteins, but these are distantly related phylogenetically to their archaeal and eukaryotic counterparts at best.
Conclusion/Significance: This domain level difference in evolution suggests that different forces have driven the evolution of DNA replication proteins in each of these two domains. In addition, the phylogenies of all three gene families support the distinctiveness of the proposed archaeal phylum Thaumarchaeota.
|Short Title||PLoS ONE|